Through linear regression analysis, we identified 34 genes with high-correlation interactions between RNA methylation and gene expression, among which 16 genes (CLDN5, GLP2R, TMPRSS6, MPP2, SorCS1, CNGA3, MYO3A, SEMA3E, ABCB5, ASPA, NRG2, SEMA3D, SLC11A1, RERG, VPS45, CBX6) have been reported to be associated with CRC. The gene discussed is NRG2; the disease is colorectal carcinoma.