CSF1R and Mental deterioration: The initial symptoms of CSF1R-microglial encephalopathy often present as progressive cognitive decline, depression, apathy, anxiety, irritability, behavioral abnormalities, and personality changes, followed by or occurring concurrently with motor symptoms, such as muscle rigidity, bradykinesia, gait disturbances, and ataxia (Konno et al., 2018a; Rosenstein et al., 2022).