In the comparative analysis of clinical data between first Group (non-thrombus) and Group second and third (thrombus status group) Table 1, univariate analysis identified significant associations with the following variables: permanent atrial fibrillation (AF), heart failure, B-type natriuretic peptide (BNP), uric acid, and D-dimer, Mitral regurgitation, LVEF, LVED, LAD, CHA2DS2-VASc score, Left atrial appendage filling velocity, Left atrial appendage emptying rate with all showing statistical significance (p < 0.05). The gene discussed is NPPB; the disease is Mitral regurgitation.