The results of the univariate analysis revealed statistically significant differences (p < 0.05) between the oral frailty group and the nonoral frailty group in the following variables: age, marital status, educational level, self-care ability, dentures, dry mouth, comorbidities, MNA-SF score, RPFS-CV score, Hospital Depression Scale score, upper limb grip strength, hemoglobin, albumin, and serum calcium. This evidence concerns the gene ALB and depressive disorder.