GPX4 and Sepsis: Clinically, sepsis patients with elevated serum iron and decreased GPX4 activity demonstrated worse pulmonary outcomes (e.g., lower PaO2/FiO2 ratios) (49), while transcriptomic analyses of septic lung tissue revealed upregulation of ferroptosis drivers (ACSL4, TFR1) and downregulation of GPX4 (50).