The multivariate analysis revealed that the occurrence of atrial fibrillation was dependent on age (P = 0.0025), smoking (P < 0.0001), and cholesterol levels (P = 0.0182), but independent of sex (P = 0.2094), ejection fraction (P = 0.2293), the presence of hypertension (P = 0.1142), chronic kidney disease (P = 0.6935), diabetes mellitus (P = 0.9375), triglyceride levels (P = 0.7614), high-sensitivity cardiac troponin I (hs-cTnI, P = 0.4422), and creatine kinase (CK, P = 0.7420). The gene discussed is TNNI3; the disease is chronic kidney disease.