USP7 and allergic disease: The USP7-STAT3-Granzyme-PAR-1 axis significantly influenced Th2 cell differentiation by regulating the production and activity of GzmA and GzmB, as well as the phosphorylation of STAT3 by USP7, particularly in the production of IL-5 and IL-13, which played a key role in allergic diseases [58] (Fig. 2).