When interacted with O-GlcNAc transferase (OGT), Cul5 promoted Lys48-linked polyubiquitination of OGT, blocked OGT's role in activating mitochondrial antiviral signaling protein O-GlcNAcylation and RIG-I signaling, reduced type I IFN expression, and promoted neutrophil-induced inflammations in asthma exacerbation [76]. This evidence concerns the gene OGT and asthma.