GATA3 and allergic asthma: Further studies showed that SOX12 promoted GATA3 ubiquitination mediated by E3 ubiquitin ligase F-Box and WD repeat domain containing (Fbw) 7 and induced GATA3 degradation through proteasome pathway, thus inhibiting Th2 cell differentiation and development of allergic asthma [60] (Fig. 2).