IDH1 and central nervous system cancer: More recently, the potential role of 1H-MRS in detecting 2-hydroxyglutarate (2-HG), the product of IDH-1 or -2 mutations in gliomas, was reported.33–36 To date, there are few studies exploring the role of 1H-MRS in tumor epileptogenesis and evaluating brain neurotransmitters in peritumoral tissue.