For CD2 and CD3, the human genes of S100A9 (calcium binding protein A9) [46] and IGHG1 (immunoglobulin heavy constant gamma 1) [47] have previously identified as genes of interest as is the case with REG1A (pancreatic stone protein) for type-1 diabetes [48]. The gene discussed is S100A9; the disease is type 1 diabetes mellitus.