Whether or not FAP-specific CAR-T cells may function in DMD is unpredictable considering the large territory of the target tissue, and because DMD is associated with significant perturbations of the immune system such as local inflammatory infiltrates in muscle tissues as well as the presence of transforming growth factor β (TGF-β) and of regulatory T lymphocytes (TLs) which may hamper immunotherapeutic approaches.8 This evidence concerns the gene FAP and Duchenne muscular dystrophy.