Activated microglia produces pro-inflammatory cytokines like interleukin-1b (IL-1b), tumor necrosis factor alpha (TNF-a), and interleukin-6 (IL-6). Elevated cytokines are generally associated with various neuroinflammatory conditions and neurodegenerative diseases (Smith et al 2012). The gene discussed is IL1B; the disease is neurodegenerative disease.