Although one study has revealed elevated plasma NfL levels in patients with PD and EDS (Lin et al., 2024), the relationship between NfL levels and specific neuroimaging markers (Preische et al., 2019; Sampedro et al., 2020; Cruz-Gomez et al., 2021; Lee et al., 2022; Clarelli et al., 2024; Yao et al., 2024) has only been explored in patients with cognitive dysfunction (Mielke et al., 2019). The gene discussed is NEFL; the disease is Parkinson disease.