SNCA and Alzheimer disease: For example, emerging evidences have supported that AD brains frequently share the pathology (co-pathology) associated with other dementias such as Lewy body dementia (LBD) and frontotemporal lobe dementia (FTLD) through the interplay among Aβ, tau, α-synuclein and TAR DNA-binding protein of 43 kDa (TDP-43) (Robinson et al., 2018; Sengupta and Kayed, 2022).