Although some studies have reported contradictory results regarding the potential of degus as a model for AD research (Steffen et al., 2016; Bourdenx et al., 2017), degus with the higher risk APOE4 allele and wild-captured or early generations after the wild-capture may frequently develop the AD pathology (Hurley et al., 2022). This evidence concerns the gene APOE and Alzheimer disease.