TERT and cancer: Recently, molecular profiles indicating high risk, such asthe coexistence of the BRAFV600E mutation with mutations in TERT promoter regions,have been significantly associated with metastasis in patients with differentiatedthyroid cancer, thereby enhancing their prognostic value for informing surgicalapproaches and the indications for radioiodine therapy (13,38).However, there is a noticeable gap in the literature regarding molecular testsspecifically aimed at evaluating thyroid tumor behavior to identify patients whomight avoid surgery due to indolent disease.