The degradation of α-synuclein involves both the ubiquitin-proteasome system (UPS) [70] and autophagy-lysosomal systems (ALS), including macroautophagy [38], chaperone-mediated autophagy (CMA) [71], and HSC70-independent endosomal microautophagy [72]. Here, HSPA8 is linked to amyotrophic lateral sclerosis.