As HLA-B*15:01 was associated with asymptomatic SARS-CoV-2 infection in comparison to mild COVID-19 in nonhospitalized individuals of European-ancestry (4), we sought to answer fundamental questions on the abundance and clonotypic nature of CD8+ T cell responses in HLA-B*15:01-positive COVID-19 patients who succumbed to life-threatening COVID-19. The gene discussed is HLA-B; the disease is COVID-19.