In line with previous reports describing TCRαβ repertoires from prepandemic and COVID-19 vaccinated individuals within B15/S919+CD8+ T cells (4, 5), the ex vivo TCR repertoire from prepandemic samples was strongly biased toward clonotypes expressing TRAV9-2 paired with TRBV7-2 (33.3%), which we refer to as one of the key public TCR pairings for B15/S919+CD8+ T cells (Fig. 2A and Dataset S1). Here, CD8A is linked to COVID-19.