A subset of COVID-19 patients were also analyzed for their TCRs ability to cross-react to B15/S919 and hCoV B15/S1012; in alignment with previous findings, cross-reactive TCRs were identified across a number of clusters (#1, 2, 4, 5, 7, 10, 11, 16) including one of the key public motif pairings, TRAV9-2/TRBV7-2 from cluster 1 (SI Appendix, Fig. S2C). Here, TRAV9-2 is linked to COVID-19.