SMAD3 and Hepatic fibrosis: Another flavonoid, namely naringenin (20) displayed preventative activity against dimethylnitrosamine (DMN)-induced liver fibrosis and at doses of 20, 50 and 100 mg/kg mediated through blockage of TGF-β-Smad3 and JNK-Smad3 signaling pathways [80,81].