Additionally, studies have shown that many plant saponins have the effect of reducing inflammatory factors and alleviating inflammation [52,53], and PSB4 shows a similar effect, it has been reported that it can downregulate the release of IL-1β, IL-6, and TNF-α in mice with ulcerative colitis and has anti-inflammatory and immunoregulatory effects [33]. This evidence concerns the gene IL1B and ulcerative colitis.