In this issue, Wang et al. show that the heterozygous deletion of the murine analog Ppp2r1a in forebrain excitatory neurons of mice (hereafter referred to as NEX-het-cKO mice) results in impairments in spatial learning and memory that model PPP2R1A-associated intellectual disability in humans (Figure 1A) (11). This evidence concerns the gene PPP2R1A and Intellectual disability.