For instance, GPR43 binds to short-chain fatty acids to enhance insulin secretion in cells (9); GPR75 can recognize 20-HETE and regulates obesity (10); and GPR40 and GPR120 can improve glycemic control, increase insulin sensitivity, and reduce inflammation via incretin release (11–13). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.