When these precursors are engaged, they ensure persistent production of cells with a TRIM phenotype, increasing the likelihood of persistent inflammatory responses, as demonstrated in TRIM induced by Nef-carrying EVs (9), stroke (33), myocardial infarction (61), enterovirus (14), elevated plasma levels of cholesterol (38, 62), and glucose (63). This evidence concerns the gene TRAT1 and myocardial infarction.