IGFBP6 and Sepsis: To investigate the role of IGFBP6 in sepsis pathogenesis, we established a murine sepsis model induced by cecal ligation and puncture (CLP) and observed significant elevation of IGFBP6 levels in the serum, peritoneal lavage fluid (PLF), and key organs (lung and spleen) during sepsis progression (Figure 3, A and B).