GPT and Sepsis: Correspondingly, biochemical biomarkers of hepatocellular injury (alanine aminotransferase [ALT] and aspartate aminotransferase [AST]) and generalized cellular damage (lactate dehydrogenase [LDH]) were markedly decreased in Igfbp6–/– mice relative to WT controls (Figure 3L), collectively indicating that IGFBP6 depletion mitigates sepsis-associated organ dysfunction.