IGFBP6 and Sepsis: ROC curve analysis confirmed the superior diagnostic accuracy of IGFBP6 for pediatric sepsis, with the discovery and validation cohorts showing AUCs of 0.90 (95% CI, 0.85-0.96) and 0.96 (95% CI, 0.94–0.98), respectively (Supplemental Figure 2, E and F).