Various anti-tumor drugs, including conventional chemotherapy agents like 5-fluorouracil, docetaxel, and paclitaxel, as well as novel targeted therapies such as lapatinib, trametinib, and Wee1 inhibitor, have demonstrated therapeutic efficacy against various malignancies, including CRC and CRLM [61–63]. This evidence concerns the gene WEE1 and neoplasm.