Enhanced systemic immunity was evidenced by elevated CD80+CD86+ mature DC populations in tumor-draining lymph nodes (Fig. 18e) and a maximal M1/M2 ratio (41.8% iNOS+CD206− cells) within SINM + US tumors (Fig. 18f), indicating durable tumor immune microenvironment (TIME) remodeling. Here, NOS2 is linked to neoplasm.