MMP2 and glioblastoma: Capitalizing on this mechanism, Fan et al. developed MMP-2-responsive nanoparticles (S-biAb/dEGCG@NPs) integrating anti-B7-H3 × CD3 BiAbs, a dimer of epigallocatechin gallate (dEGCG), and hyaluronic acid-PLGLAG-dEGCG conjugates to potentiate immune tolerance reversal and ferroptosis in glioblastoma (Fig. 17a) [51].