IL1RN and thyroid cancer: Regarding the causal relationship between IL-1RA and thyroid cancer, the IVW model showed that for each unit increase in IL-1RA, the risk of developing thyroid cancer increased by 1.2164 times, with statistical significance (odds ratio [OR] = 1.2164, 95% confidence interval [CI]: 1.0020–1.4767, P = 0.0477).