IL1B and peritonitis: To examine NLRP3 inhibition in vivo, we performed a well-characterized model of peritonitis using i.p. injection of LPS followed by ATP, where IL-1β production in the peritoneal cavity is NLRP3 dependent (Fig. 6 A) (Daniels et al., 2016; Pan et al., 2007; Perregaux et al., 2001).