A number of these mutations (D303H, K568N, and Y570C) are known to cause the severe NLRP3-AID neonatal-onset multisystem inflammatory disease (Infevers Database) and include several somatic mutations (D303H, K565E, E567G, K568N, and Y570C) (Cosson et al., 2024). The gene discussed is NLRP3; the disease is Neonatal onset.