EGFR and carcinoma: In a previous study, a dramatic elevation of mutated EGFR at the protein level was detected after 2 weeks of DOX induction in EC mice, and the early precancerous atypical adenomatous hyperplasia (AAH) lesions started to appear.39 To investigate whether UC-MSCs promote the occurrence of carcinoma, lung density was monitored by CT scanning at indicated time points since the EC mice were fed a diet with DOX (Figures 1A, 2A).