However, even though we did not test the development of lung adenocarcinoma after the formation of solid micro-adenocarcinoma, the local inflammation, as indicated by the continuous high level of Ifnγ, Ccl2, and Ccl5, suggests that the risk of TME reprogramming with MSCs may increase after the solid tumor appears with the exhaustion of immune cells. The gene discussed is CCL5; the disease is adenocarcinoma.