By analyzing three single‐cell datasets, we uncovered that TGFβ1+ Tregs orchestrate CD8+ T cell impairment through critical receptor‐ligand signaling, including LGALS9‐HAVCR2 and TNFSF10‐TNFRSF10B, thereby reinforcing immunosuppression in CRC. Here, HAVCR2 is linked to colorectal carcinoma.