Moreover, LGALS9‐HAVCR2 (Galectin‐9‐TIM‐3) serves as a pivotal regulator of T cell exhaustion, with elevated TIM‐3 expression in various malignancies strongly correlating with poor prognosis and functional exhaustion of CD8+ tumor‐infiltrating lymphocytes (TILs). This evidence concerns the gene HAVCR2 and neoplasm.