As a chronic autoimmune model, they used the pristane-induced mouse model of SLE, which is TLR7-dependent (Savarese et al., 2008), and found that bone marrow macrophages from these mice exhibited hallmark features of trained immunity, such as enhanced bacterial killing and inflammatory cytokine production, linked to increased glycolysis. Here, TLR7 is linked to systemic lupus erythematosus.