Compared with HER2‐positive cancers, HER2‐low cases showed low Ki‐67, ER/PR positivity, low Emax, and a DVPC pattern characterized by an initial increase followed by a subsequent decline as independent predictors (p < 0.05), with an AUC of 0.929, sensitivity 0.905, and specificity 0.856. This evidence concerns the gene PGR and cancer.