To further verify the above hypothesis, we constructed a system of co‐culturing NPCs and P. acnes at a 100 : 1 multiplicity of infection (MOI) for different time periods (36 and 72 h), and observed that the mRNA expression for PGC‐1α, NRF1/2, and TFAM was also reduced in a time‐dependent manner (Fig. 2E), similar to our results with western blotting (Fig. 2F). The gene discussed is NRF1; the disease is infection.