Further support to the role of granulins in TDP‐43 proteinopathies comes from in vitro studies where a direct interaction between recombinant proteins of TDP‐43 C‐terminal domain and granulins were demonstrated, and individual granulins were found to differentially modulate TDP‐43 liquid–liquid phase separation and its assembly into ThT‐positive aggregates [124]. The gene discussed is GRN; the disease is proteostasis deficiencies.