Subsequent work by the same group utilised a cellular model to look at the proteome remodeling due to RAD‐23 loss and identified deubiquitinase USP13 as a strong modifier of TDP‐43 aggregation and cytotoxicity, with reproducible results in HEK293 cell model, primary rat neurons and C. elegans ALS models [278]. Here, TARDBP is linked to amyotrophic lateral sclerosis.