The transgenic worms accumulated detergent‐insoluble aggregates of full‐length as well as truncated and high molecular weight aggregated forms of TDP‐43 [192], a characteristic feature of ALS and FTLD‐U [11], with wild‐type TDP‐43 preferably isolating in the insoluble fraction. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.