Some of these advanced approaches, like the optogenetic TDP‐43 modulation in C. elegans that resulted in light‐induced ALS pathology in relation to motor impairment, reduced lifespan and TDP‐43 inclusions in cell bodies and neurites, which were otherwise absent [313], are being implemented to refine disease modeling, offering more physiologically relevant models for studying disease mechanisms and therapeutic interventions. Here, TARDBP is linked to amyotrophic lateral sclerosis.