For instance, STMN2 cryptic exon inclusion—a hallmark of TDP‐43 loss‐of‐function in human ALS/FTD neurons—is not observed in TDP‐43 knockdown mice due to a lack of conserved intronic sequences flanking the cryptic exon [227, 228]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.