TARDBP and frontotemporal dementia: TDP‐43, however, gained prominence in 2006 when it was identified as the main constituent protein of the ubiquitinated inclusions observed in the neurons and glial cells of sporadic amyotrophic lateral sclerosis (ALS) patients and in patients with frontotemporal lobar degeneration with ubiquitin‐positive inclusions (formerly FTLD‐U, now classified as FTLD‐TDP) [8, 9, 10, 11, 12], a common neuropathological subtype of frontotemporal dementia (FTD).