Similarly, transgenic C. elegans over‐expressing pan‐neuronally the wild‐type or ALS‐associated mutant TDP‐43 variants (Q331K and M337V) tagged with yellow fluorescent protein (YFP) at C‐terminus show neurotoxicity manifested by locomotor defects, defective synaptic transmission, slow growth and accumulation of detergent‐insoluble aggregates in the absence of frank neurodegeneration, with mutant YFP‐TDP‐43 variants inducing more toxicity than the wild‐type YFP‐TDP‐43 [143], similar to the untagged TDP‐43 variants described earlier [132, 192]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.