Additionally, transgenic C. elegans over‐expressing YFP‐tagged TDP‐C25 (residues 219–414), a truncated aggregation‐prone C‐terminal TDP‐43 fragment found in ubiquitinated inclusions in brain and spinal cords of FTLD and ALS patients [11], had moderate toxicity than the full‐length YFP‐tagged TDP‐43 over‐expressing worms despite accumulating more insoluble or less diffusible aggregates [143]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.