This multidomain architecture allows TDP‐43 to engage in numerous aspects of RNA metabolism, including transcriptional regulation, RNA splicing, RNA transport, RNA stability and translation [81, 82], and many others, such as its recently reported direct involvement in the cryptic splicing event of UNC13A [83], a potent genetic risk factor for ALS and FTD [84, 85]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.