TARDBP and amyotrophic lateral sclerosis: CTD is also pathologically highly relevant since most of the disease‐linked TDP‐43 mutations [127] and phosphorylation sites are clustered in CTD, and also the catalytic C‐terminal fragments of approx. sizes 25–35 kDa make up the bulk of the inclusion bodies found in ALS‐affected brains [128, 129].