In a different study by Kraemer and colleagues [192], transgenic C. elegans lines were generated to compare the pathology induced by wild type TDP‐43 against three common pathogenic mutant variants implicated in familial ALS in relation to G290A [193], A315T [24, 194], and M337V [22, 167]. Here, TARDBP is linked to amyotrophic lateral sclerosis.