In a different study, TDP‐43 was tested to understand the susceptibility to neurotoxicity induced when combined with tau, A‐β or poly‐glutamine—proteins implicated in multiple neurodegenerative diseases [236]—and the fact that TDP‐43 co‐pathology worsens the clinical symptoms in AD [49, 50]. This evidence concerns the gene TARDBP and neurodegenerative disease.