Using a similar RNAi‐mediated one gene depletion approach, a potential role of AMPK in TDP‐43 induced toxicity was investigated using worms deficient in aak‐2 (C. elegans AMPK α2 orthologue), for reasons that some ALS patients possess metabolic defects [265] and AMPK being a well‐known metabolite sensor [266]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.