TARDBP and amyotrophic lateral sclerosis: In one such example, out of the three compounds that were tested in C. elegans and zebra fish TDP‐43 models, namely lithium chloride, methylene blue and the FDA approved drug for ALS patients riluzole, methylene blue mitigated the TDP‐43‐induced neurotoxic effects in both the models [291], in a mechanism involving endoplasmic reticulum (ER) stress response [292].