TARDBP and amyotrophic lateral sclerosis: Concerning ALS/FTLD, the pathological lesions in these diseases consist of TDP‐43 inclusions along with UBIQUILIN‐2 (UBQLN2) [231], another protein implicated in ALS or ALS/FTLD [231, 232, 233], and in this case the two proteins are known to also interact physically in vitro [234].