CTD is required for the splicing activities of TDP‐43 [110, 111] and self‐regulation of its own mRNA levels [112] as well as of other disease‐associated proteins for example tau [113], a protein implicated in multiple neurodegenerative diseases referred to as tauopathies (for a review please see [114]). The gene discussed is TARDBP; the disease is neurodegenerative disease.