The aims of this study were to investigate the role of TMs and identify the molecular drivers involved in TM formation.<h4>Methods</h4>We used patient-derived GBM neurosphere cultures that produce TMs to investigate TM dynamics, the proteins and pathways involved in TM formation, and the effect of targeting brain fatty acid-binding protein (FABP7) on mouse survival using an orthotopic model of GBM.<h4>Results</h4>The radial glial cell marker, FABP7, is highly expressed in TMs. The gene discussed is FABP7; the disease is glioblastoma.