Evidence of significant fibrosis (2015: only cirrhosis) (≥F2b) based on an APRI score of > 0.5 or transient elastography value of > 7 kPa or evidence of cirrhosis (F4) based on clinical criteria (or an APRI score of > 1 or transient elastography value of > 12.5 kPa), regardless of HBV DNA or ALT levels’. This evidence concerns the gene GPT and Cirrhosis.