Further studies, such as those carried out with rats challenged with a hyperlipidemic and atherogenic diet and analyzing additional related parameters, such as PLA2 and LCAT activities, at different time points, would be of interest to provide more insights into the pathophysiological significance of the increased LysoPC(20:0), LysoPC(20:0)-sn2, LysoPC(23:0), and LysoPC(24:0) circulating levels concerning CVD and cancer risks in the framework of menopausal transition and postmenopause. The gene discussed is LCAT; the disease is cancer.