MTOR and diabetes mellitus: In parallel, MD did not significantly alter hepatic levels of autophagy modulators (mTOR, AMBRA, and p62) as, at multiple levels, diabetes and WD did, stimulating, at the same time, AMPK activity (Thr172 phosphorylation), a crucial control point for liver lipid catabolism, oxidative capacity, mitophagy, and autophagy, very recently shown to be targeted by several plant metabolites eliciting hepatoprotective effects against fatty liver [58, 59].