NR1H4 and metabolic dysfunction-associated steatohepatitis: More recently, in preclinical models of NASH, bile acid composition in the enterohepatic circulation was found to be profoundly altered, with specific depletion of secondary bile acids, which are known to exert anti‐inflammatory effects [48]. In addition, unlike physiological or therapeutic concentrations of FXR and TGR5 receptor agonists, which may elicit protective effects on mitochondria [49], excessive chenodeoxycholic acid or dysregulated bile acid metabolism has been associated with mitochondrial dysfunction [50].