NUP107 and amyotrophic lateral sclerosis: To further investigate the potential in vivo relevance of Nup107, we next turned to a well‐established C. elegans model of C9‐ALS expressing 75 repeats of the G4C2 HRE under the ubiquitous snb‐1 promoter (C9ubi) [70] (Fig. 4A).