MAPT and Alzheimer disease: 2022; Tommasi et al., 2021; Yasuno et al. 2020). In relation to hyperactivity, AD pathologies appear to be less associated with its manifestation compared to other risk factors such as phosphorylated TDP‐43 (Sennik et al. 2016; Borges et al. 2019). Similarly, psychosis may also arise from alternative mechanisms. For instance, structural (cortical thickness) and pathological abnormalities (tau, α‐synuclein) have been shown to influence psychosis differently in a sex‐dependent manner (Whitehead et al. 2012; Koppel et al. 2014).