Fetal EV treatment resulted in a total of 12 shared pathways, 5 of which were shared exclusively with each other, namely downregulation of the “neutrophil extracellular trap signalling”, “HOTAIR regulatory”, “tumour microenvironment”, “ferroptosis signalling” and “leukocyte extravasation signalling” pathways, showing a clear clustering of fetal versus perinatal EVs in the enriched pathways (Fig. 4A-E, Table S7, for individual molecules responsible for the activation or inhibition of specific pathways see Tables S9-S9). This evidence concerns the gene HOTAIR and neoplasm.