fMSC-EVs treated cells dominated the comparative canonical pathway list with inhibition of various proinflammatory pathways such as the “role of chondrocytes in rheumatoid arthritis” and “osteoarthritis” pathways and activation of the “IL-10” and “extracellular matrix organization” pathways (Fig. 6, Table S8, for individual molecules responsible for the activation or inhibition of specific pathways see Tables S13-S16). This evidence concerns the gene IL10 and osteoarthritis.