TGFB1 and neoplasm: Specifically, Detox-iCAF and IL-iCAF are predominantly located in the peritumor conjunctive tissue; the ECM-myCAF are enriched in the tumor bed; TGFβ-myCAF are distributed both within the tumor and adjacent to normal lobules; Wound-myCAF reside in large nests of intra-tumoral stroma, while ECM-myCAF and IFNαβ-myCAF are commonly observed in tumor cell-enriched regions [5].