Furthermore, a recent pan-cancer study revealed four spatially distinct CAF subtypes, among which s1-CAFs and s2-CAFs showed consistent characteristics with myCAFs; s3-CAFs were enriched in iCAFs genes; and s4-CAFs showed high similarity to apCAFs [3], suggesting that these CAF subpopulations may have commonalities across different cancer types. The gene discussed is TBX1; the disease is cancer.