SPP1 and neoplasm: For example, ECM-myCAF, IFNαβ-myCAF, and TGFβ-myCAF clusters co-localize with immune cells such as TREM2+ tumor-associated macrophages (TAM) and SPP1+ TAM within the tumor bed, while Detox-iCAF co-localizes with FOLR2+ TAM in immuno-protective niches [5].