Similarly, Yang et al. demonstrated that disturbed flow activates the protein kinase, AMP-activated, alpha 1 (PRKAA1)/AMP-activated protein kinase α1 (AMPKα1)-hypoxia-inducible factor α (HIFα)-glycolysis axis that supports EC proliferation, and inhibition of PRKAA1 accelerates atherosclerosis in ApoE−/− mice [41]. This evidence concerns the gene PRKAA1 and atherosclerosis.