Supporting the role of exosomes in PAH, PAH rat-derived EVs cargo are enriched of proteins and miRNA associated with PAH pathogenesis, including cellular respiration and vasculature remodeling (complement family, hemopexin, ceruloplasmin protein, miR-145, miR-451, miR-10b, miR-486-5p, mir-26a and miR-342) [148–150]. This evidence concerns the gene CP and pulmonary arterial hypertension.