CLIC4 and systemic sclerosis: The media from SSc fibroblasts was able to significantly increase pSTAT1 and pSMAD3 levels (4.9-fold p = 0.01, 2.43-fold p = 0.018 respectively) compared to mock in HaCaT transfected with control siRNA but the increase in the HaCaT transfected with CLIC4 siRNA was not significant (1.88-fold p = 0.09, 0.68-fold p = 0.12 respectively).