Studies performed using the pilocarpine model of temporal lobe epilepsy, when the animals display spontaneous seizures, also showed an upregulation in GluN2B-mediated responses in the lateral perforant path synapses with hippocampal dentate granule neurons [32], and similar changes account for the facilitation of NMDAR-dependent LTP of Schaffer collateral-CA1 synapses [23, 46]. The gene discussed is GRIN2B; the disease is temporal lobe epilepsy.