A similar response has already been described in locusts, where the Toll pathway is activated in fat bodies and haemocytes in response to the infection [42] and it contributes to: (i) the production, in conjunction with the ecdysone pathway, of antifungal peptides; (ii) the triggering of behavioral fever to slow down the infection [43]; and (iii) haemocyte differentiation. This evidence concerns the gene TLR4 and infection.