ATF6 and colorectal carcinoma: In a hypothesis-free approach, ATF6 was identified among the most significant transcription factors, as calculated using a linear mixed-effects model, whose activities correlated positively with the presence of CRC-enriched genera, including Campylobacter, Porphyromonas, Fusobacterium, Selonomonas and Desulfovibrio (Fig. 5g,h).