FASN and neoplasm: To understand the causal role played by FASN in colonic tumorigenesis in our nATF6IEC mouse model, we exposed fl/fl and tg/tg SPF mice to biweekly intraperitoneal (i.p.)injections of the FASN inhibitor C75 from the age of 3 weeks (pre-tumour time point) until 12 weeks (tumour time point; Fig. 4g).