KEAP1 and lung carcinoma: In light of the fact that NRF2 is regulated at the level of protein stabilization, in order to gain the most basic insight into a potential role of Sotorasib in NRF2 function, we treated lung cancer cells with a functioning KEAP1-NRF2 system with Sotorasib, and performed an immunoblot for NRF2 stabilisation (Fig. 1b).