NFE2L2 and cancer: Of note, as monocyte-derived cells can be broadly divided into two classes, anti-cancer M1 and pro-cancer M2 [28, 31], and both IL10 and TGFβ signaling are associated with the M2-lineage, these data suggest that NRF2 inducers function to promote myeloid anti-cancer immunity by repolarizing cells from the M2 to the anti-cancer M1 phenotype.