TSC1 and autism: In addition to our findings, another study has found that inhibition of the excitatory neurons in the left medial prefrontal cortex (mPFC) ameliorated social deficits and repetitive behaviors in Purkinje cell-Tsc1 mutant mice.51 These findings raise the possibility that differential hemispheric susceptibility to ASD-related genetic perturbation could contribute to the pervasive asymmetrical changes observed in the brains of autism patients.