We then queried the STRING database for protein–protein interactions (PPIs) of these asymmetrically phosphorylated autism-related proteins and performed a hub analysis.28 Notably, the asymmetric phosphorylation of most postsynaptic proteins, such as SHANK2, SHANK3 and CaMK2B, was left-higher (Fig. 1e). Here, SHANK3 is linked to autism.