Univariate analysis showed that planned transcatheter heart valve intervention (p <0.001), older age (p <0.001), severely reduced LVEF (p = 0.003), known cardiac arrhythmia (p = 0.010), cTnT levels (p = 0.030), known chronic kidney disease (p = 0.032), and planned cardiac catheterization (p = 0.041) were associated with CHF with clinical progress during the waiting time (NT-proBNP level > 900 pg/ml in combination with worsening of clinical symptoms, including dyspnea, emergency heart failure hospitalization, and LVEF) (supplementary table 1). The gene discussed is TNNT2; the disease is heart failure.