Binary logistic regression analysis was performed to identify predictors of clinically progredient CHF, indicated by an NT-proBNP level of > 900 pg/ml on the actual intervention date in combination with worsening of dyspnea as assessed by NYHA class, emergency heart failure hospitalization, or declining left ventricular ejection fraction (LVEF) during the waiting time. Here, NPPB is linked to heart failure.