Another study utilized an epigenetic strategy using non-coding RNAs (ncRNAs) to dually target the CD155/TIGIT and PD-1/PD-L1 axes, and inhibition of PD-1/PD-L1 and TIGIT/CD155 expression was observed in HCC, resulting in enhanced cellular toxicity [95]. Here, PVR is linked to hepatocellular carcinoma.